Research Articles
BatMeth2: A Comprehensive Guide to Indel-Sensitive BS-Seq Alignment for Methylation Analysis
This article provides a complete resource for researchers and bioinformaticians utilizing BatMeth2, an integrated software package for bisulfite sequencing data analysis.
Read-Position-Aware Quantitation: Revolutionizing Single-Cell Bisulfite Sequencing Data Analysis
Single-cell bisulfite sequencing (scBS) unlocks the potential to study epigenetic heterogeneity at unprecedented resolution.
Methylation Density Analysis in Gene Bodies and Flanking Regions: From Foundational Concepts to Clinical Applications
This comprehensive review explores methylation density analysis in gene bodies and their flanking regions, a critical epigenetic mechanism governing gene regulation, cellular differentiation, and disease pathogenesis.
Uncharted Epigenetic Territories: A Guide to Methylation Analysis in Non-Model Organisms
This article provides a comprehensive roadmap for researchers and drug development professionals embarking on DNA methylation studies in non-model organisms.
Decoding Cellular Diversity: A Guide to DNA Methylation Clustering and Gene Module Signatures
This article provides a comprehensive resource for researchers and drug development professionals exploring the analysis of DNA methylation signatures through clustering and gene module detection.
Identifying Variably Methylated Regions (VMRs) in scBS Data: A Comprehensive Guide from Foundational Concepts to Advanced Applications
This article provides a comprehensive guide for researchers and bioinformaticians on identifying and analyzing Variably Methylated Regions (VMRs) from single-cell bisulfite sequencing (scBS) data.
From Data to Discovery: A Comprehensive Guide to Methylation Level Heat Maps and Metagene Analysis
This article provides a comprehensive guide for researchers and drug development professionals on generating and interpreting methylation level heat maps and metagene profiles.
Mining Genome-Wide DNA Methylation Patterns: From Foundational Technologies to Clinical Applications
This article provides a comprehensive guide for researchers and drug development professionals on mining genome-wide DNA methylation data.
Decoding the Epigenome: A Comprehensive Guide to Methylation Coverage Signals Across Genomic Regions
This article provides a cutting-edge overview for researchers and drug development professionals on generating and interpreting average methylation coverage signal profiles across genomic regions.
histoneHMM: A Comprehensive Guide to Differential Analysis of Broad Histone Marks for Biomedical Research
This article provides a definitive resource for researchers and drug development professionals navigating the computational challenges of analyzing broad histone modifications like H3K27me3 and H3K9me3.